Upregulation of Ca removal in human skeletal muscle: a possible role for Ca -dependent priming of mitochondrial ATP synthesis
نویسندگان
چکیده
Werner J. H. Koopman,1,2 Michel Renders,2 Arie Oosterhof,2 Toin H. van Kuppevelt,2 Baziel G. M. van Engelen,3 and Peter H. G. M. Willems1,2 1Microscopical Imaging Center and 2Department of Biochemistry, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen; and 3Institute of Neurology, Neuromuscular Center Nijmegen, University Medical Center Nijmegen, NL-6500 HB Nijmegen, The Netherlands
منابع مشابه
Upregulation of Ca2+ removal in human skeletal muscle: a possible role for Ca2+-dependent priming of mitochondrial ATP synthesis.
In muscle, ATP is required for the powerstroke of the myosin head, the detachment of actin and myosin filaments, and the reuptake of Ca2+ into the sarcoplasmic reticulum. During contraction-relaxation, large amounts of ATP are consumed at the sites of action of the myosin-ATPase and sarcoplasmic reticulum Ca2+-ATPase. The present study addresses the consequences of a reduction in mitochondrial ...
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تاریخ انتشار 2003